Studies of the influence of different cross-linking reagents on the immune response against a B-epitope.

Abstract : We have previously shown that the carrier polytuftsin obtained by polycondensation of tuftsin, a naturally occurring macrophage activator, increases significantly the antibody response against a linked B-epitope. In the present work, we have studied the influence of different cross-linking reagents on the quality of the conjugation and on the immune response, at both B-cell and T-cell levels. We observed that the cross-linking method used for coupling the B-epitope to the carrier influences the immune response. A hypothesis is put forward to explain the differences observed.
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Submitted on : Tuesday, June 4, 2019 - 12:00:13 PM
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A. Delmas, A. Brack, Y. Trudelle. Studies of the influence of different cross-linking reagents on the immune response against a B-epitope.. Bioconjugate Chemistry, American Chemical Society, 1992, 3 (1), pp.80-4. ⟨10.1021/bc00013a013⟩. ⟨hal-02146933⟩

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