Influence of the conformation of a macromolecule on the generation of T-cell proliferative response. A study with model polypeptides.

Abstract : To study the influence of the conformation of polypeptidic macromolecules on the generation of T-cell epitopes, sequential polypeptides with an octamer repeat unit were designed and synthesized. They adopt mainly unordered and alpha-helical conformations. Among these polypeptides, those containing proline are fully or partly unordered, and are more effective at inducing T-cell proliferation than a proline-free very stable alpha-helical polypeptide. This extremely stable alpha-helical conformation, probably stabilized by aggregation, would enhance its stability against proteolytic processing.
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https://hal.archives-ouvertes.fr/hal-02146930
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Submitted on : Tuesday, June 4, 2019 - 11:58:37 AM
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  • HAL Id : hal-02146930, version 1
  • PUBMED : 7519569

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E Lacassie, A. Delmas, Y. Trudelle. Influence of the conformation of a macromolecule on the generation of T-cell proliferative response. A study with model polypeptides.. FEBS Letters, Wiley, 1994, 349 (3), pp.380-4. ⟨hal-02146930⟩

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