Increased osteopontin expression in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patient cells is associated with IL-17 expression

Sarkis Sarkis (1) , Gildas Belrose (2) , Jean-Marie Peloponese (3) , Stéphane Olindo (2, 4) , Raymond Césaire (2) , Jean-Michel Mesnard (1) , Antoine Gross (3)

1 CPBS - Centre d’études d’Agents Pathogènes et Biotechologies pour la Santé
2 EA 4537 - Laboratoire de Virologie-Immunologie [Fort de France, Martinique]
3 IRIM - Institut de Recherche en Infectiologie de Montpellier
4 Service de neurologie [Fort-de-France, Martinique]

HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a neurological inflammatory disease associated with a predominant infiltration of CD4+ T lymphocytes, which are the main subset of HTLV-1-infected cells. It has been demonstrated that in cell line the viral Tax protein transcriptionnally regulate expression of osteopontin, an inflammatory cytokine associated with Th17-related pathologies.

Mots clés: HAM/TSP; HTLV-1; IL-17; Osteopontin

Domaines: Maladies infectieuses

Sarkis Sarkis, Gildas Belrose, Jean-Marie Peloponese, Stéphane Olindo, Raymond Césaire, et al.. Increased osteopontin expression in HTLV-1-associated myelopathy/tropical spastic paraparesis (HAM/TSP) patient cells is associated with IL-17 expression. Journal of Clinical Virology, 2013, 58 (1), pp.295-298. ⟨10.1016/j.jcv.2013.05.006⟩. ⟨hal-02146262⟩