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Calcium phosphate biomaterials as bone drug delivery systems: a review

Abstract : A short review is proposed on the existing literature for the research performed in calcium phosphate (CaP) biomaterials used as drug delivery systems. In the first part, a brief update is given on the performance of both CaP ceramics and CaP cements. Second, a review of the research and clinical situation is developed for CaP materials already used as drug delivery systems. Experimental works performed for local delivery are reported. In particular, a description is given of the in vitro and in vivo studies in which these materials are loaded with various proteins and drugs.
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https://hal.archives-ouvertes.fr/hal-02142555
Contributor : Jean Michel Bouler <>
Submitted on : Tuesday, May 28, 2019 - 4:47:44 PM
Last modification on : Tuesday, September 17, 2019 - 9:18:01 AM

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Elise Verron, Ibrahim Khairoun, Jerome Guicheux, Jean-Michel Bouler. Calcium phosphate biomaterials as bone drug delivery systems: a review. Drug Discovery Today, 2010, 15 (13-14), pp.547-552. ⟨10.1016/j.drudis.2010.05.003⟩. ⟨hal-02142555⟩

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