, for larval feeding (ISMER/UQAR) (RT), from the RFI Food for Tomorrow

. Maliblue, STARE-CAPMED -Station of reference and research on change of local and global anthropogenic pressures on Mediterranean ecosystem drifts), and also from the European Commission under the Horizon 2020 Research and Innovation Program GHaNA (The Genus Haslea, New marine resources for blue biotechnology and Aquaculture, grant agreement, from the Territorial Collectivity of Corsica and the Rhone-Mediterranean and Corsica Water Agency

M. Auffret and R. Oubella, Hemocyte Aggregation in the Oyster Crassostrea gigas: In Vitro Measurement and Experimental Modulation by Xenobiotics, Comp. Biochem. Physiol. --Part Physiol, vol.3, pp.705-712, 1997.

S. Ban, C. Burns, J. Castel, Y. Chaudron, E. Christou et al., The paradox of diatomcopepod interactions, Mar. Ecol. Prog. Ser, vol.157, pp.287-293, 1997.

J. P. Bergé, N. Bourgougnon, S. Alban, F. Pojer, S. Billaudel et al., Antiviral and anticoagulant activities of a water-soluble fraction of the marine diatom Haslea ostrearia, Planta Med, vol.65, pp.604-609, 1999.

Z. Bouhlel, F. Turcotte, D. E. Warschawski, A. Arnold, K. Lemarchand et al., Marennine, a potential alternative antibiotic to polymyxine in aquaculture. Presented at the Aquaculture Canada, 2018.

M. Bruto, A. James, B. Petton, Y. Labreuche, S. Chenivesse et al., Vibrio crassostreae, a benign oyster colonizer turned into a pathogen after plasmid acquisition, ISME J, vol.11, pp.1043-1052, 2017.
URL : https://hal.archives-ouvertes.fr/hal-01483219

I. Buttino, J. Hwang, G. Romano, C. Sun, T. Liu et al., Detection of malformations in sea urchin plutei exposed to mercuric chloride using different fluorescent techniques, Ecotoxicol. Environ. Saf, vol.123, pp.72-80, 2016.

,

I. Buttino, A. Miralto, A. Ianora, G. Romano, and S. A. Poulet, Water-soluble extracts of the diatom Thalassiosira rotula induce aberrations in embryonic tubulin organisation of the sea urchin Paracentrotus lividus, Mar. Biol, vol.134, pp.147-154, 1999.

G. S. Caldwell, The influence of bioactive oxylipins from marine diatoms on invertebrate reproduction and development, Mar. Drugs, vol.7, pp.367-400, 2009.

G. S. Caldwell, P. J. Olive, and M. G. Bentley, Inhibition of embryonic development and fertilization in broadcast spawning marine invertebrates by water soluble diatom extracts and the diatom toxin 2-trans,4-trans decadienal, Aquat. Toxicol. Amst. Neth, vol.60, pp.123-137, 2002.

D. Carbonnelle, P. Pondaven, M. Morancais, G. Masse, S. Bosch et al., Antitumor and antiproliferative effects of an aqueous extract from the marine diatom Haslea ostrearia (Simonsen) against solid tumors: lung carcinoma (NSCLC-N6), kidney carcinoma (E39) and melanoma (M96) cell lines, Anticancer Res, vol.19, pp.621-624, 1998.

, Methods for Dilution Antimicrobial Susceptibility Tests for Bacteria That Grow Aerobically. Document M07-A9, 2012.

P. A. Wayne and U. ,

C. Falaise, C. François, M. Travers, B. Morga, J. Haure et al., Antimicrobial Compounds from Eukaryotic Microalgae against Human Pathogens and Diseases in Aquaculture, Mar. Drugs, vol.14, p.159, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01613378

J. Folch, M. Lees, and G. H. Stanley, A Simple Method for the Isolation and Purification of Total Lipides from Animal Tissues, J. Biol. Chem, vol.226, pp.497-509, 1957.

E. Fraboulet, Y. Lambert, R. Tremblay, and C. Audet, Assessment of paternal effect and physiological cost of metamorphosis on growth of young winter flounder Pseudopleuronectes americanus juveniles in a cold environment, J. Fish Biol, vol.76, pp.930-948, 2010.

B. Gaillon, Des huîtres vertes, et des causes de cette coloration, J. Phys. Chim. D'histoire Nat. Arts, vol.91, pp.222-225, 1820.

R. Gastineau, G. Hansen, N. A. Davidovich, O. Davidovich, J. Bardeau et al., A new blue-pigmented hasleoid diatom, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01905096

, Eur. J. Phycol, vol.51, pp.156-170

R. Gastineau, J. Pouvreau, C. Hellio, M. Morançais, J. Fleurence et al., Biological activities of purified marennine, the blue pigment responsible for the greening of oysters, J. Agric. Food Chem, vol.60, pp.3599-3605, 2012.
URL : https://hal.archives-ouvertes.fr/hal-00857459

R. Gastineau, F. S. Prasetiya, C. Falaise, B. Cognie, P. Decottignies et al., Part II: Marine Molecules for Disease Treatment / Prevention and for Biological Research, Chap16: Marennine-Like Pigments: Blue Diatom of Green Oyster Cult?, Biotechnologies: Production and Uses of Marine Molecules, 2018.

V. Wiley,

R. Gastineau, F. Turcotte, J. Pouvreau, M. Morançais, J. Fleurence et al., Marennine, promising blue pigments from a widespread Haslea diatom species complex, Mar. Drugs, vol.12, pp.3161-3189, 2014.
DOI : 10.3390/md12063161
URL : https://hal.archives-ouvertes.fr/hal-01616162

,

E. Gudimova, H. C. Eilertsen, T. Ø. Jørgensen, and E. Hansen, In vivo exposure to northern diatoms arrests sea urchin embryonic development, Toxicon, vol.109, pp.63-69, 2016.

,

R. Hennebicq, G. Fabra, C. Pellerin, I. Marcotte, B. Myrand et al., The effect of spawning of cultured mussels (Mytilus edulis) on mechanical properties, chemical and biochemical composition of byssal threads, Aquaculture, vol.410, issue.411, pp.11-17, 2013.

,

E. Hjörleifsson and G. Klein-macphee, Estimation of live standard length of winter flounder Pleuronectes americanus larvae from formalin-preserved, ethanol-preserved and frozen specimens, Mar. Ecol. Prog. Ser, vol.82, pp.13-19, 1992.

A. Ianora and A. Miralto, Toxigenic effects of diatoms on grazers, phytoplankton and other microbes: a review, Ecotoxicol. Lond. Engl, vol.19, pp.493-511, 2010.

P. Kasten and A. A. Flores, Disruption of endogenous tidal rhythms of larval release linked to food supply and heat stress in an intertidal barnacle, Mar. Ecol. Prog. Ser, vol.472, pp.185-198, 2013.

,

I. B. Khemis, C. Audet, R. Fournier, and J. D. Noüe, Early weaning of winter flounder (Pseudopleuronectes americanus Walbaum) larvae on a commercial microencapsulated diet, 2003.

, Aquac. Res, vol.34, pp.445-452

P. H. Mitchell and R. L. Barney, The occurrence in Virginia of green-gilled oysters similar to those of Marennes, Govt. print. off, 1917.

B. Morga, I. Arzul, B. Chollet, and T. Renault, Infection with the protozoan parasite Bonamia ostreae modifies in vitro haemocyte activities of flat oyster Ostrea edulis, Fish Shellfish Immunol, vol.26, pp.836-842, 2009.

J. Mouget, R. Gastineau, O. Davidovich, P. Gaudin, and N. A. Davidovich, Light is a key factor in triggering sexual reproduction in the pennate diatom Haslea ostrearia, FEMS Microbiol. Ecol, vol.69, pp.194-201, 2009.

B. Myrand, R. Tremblay, and J. Sévigny, Impact of suspension culture using mesh sleeves on genetic characteristics of Mytilus edulis L. in Canada, Aquaculture, vol.291, pp.147-153, 2009.

,

Y. Nassiri, J. Robert, Y. Rincé, and T. Ginsburger-vogel, The cytoplasmic fine structure of the diatom Haslea ostrearia (Bacillariophyceae) in relation to marennine production, Phycologia, vol.37, pp.84-91, 1998.

C. C. Parrish, Separation of Aquatic Lipid Classes by Chromarod Thin-Layer Chromatography with Measurement by latroscan Flame Ionization Detection, Can. J. Fish. Aquat. Sci, vol.44, pp.722-731, 1987.

A. Pinsino, V. Matranga, F. Trinchella, and M. C. Roccheri, Sea urchin embryos as an in vivo model for the assessment of manganese toxicity: developmental and stress response effects, Ecotoxicology, vol.19, pp.555-562, 2010.

G. Pohnert, Diatom/Copepod Interactions in Plankton: The Indirect Chemical Defense of Unicellular Algae, ChemBioChem, vol.6, pp.946-959, 2005.

S. A. Poulet, T. Wichard, J. B. Ledoux, B. Lebreton, J. Marchetti et al., Influence of diatoms on copepod reproduction. I. Field and laboratory observations related to Calanus helgolandicus egg production, 2006.

J. Pouvreau, E. Housson, L. L. Tallec, M. Morançais, Y. Rincé et al., Growth inhibition of several marine diatom species induced by the shading effect and allelopathic activity of marennine, a blue-green polyphenolic pigment of the diatom Haslea ostrearia (Gaillon/Bory) Simonsen, J. Exp. Mar. Biol. Ecol, vol.352, pp.212-225, 2007.

,

J. Pouvreau, M. Morançais, F. Taran, P. Rosa, F. Laurent-dufossé et al., Antioxidant and Free Radical Scavenging Properties of, 2008.
URL : https://hal.archives-ouvertes.fr/hal-01188158

. Marennine, Blue-Green Polyphenolic Pigment from the Diatom Haslea ostrearia

, Simonsen Responsible for the Natural Greening of Cultured Oysters, J. Agric. Food Chem, vol.56, pp.6278-6286

J. Pouvreau, M. Morançais, J. Fleurence, and P. Pondaven, Method for the quantification of the blue-green pigment "marennine" synthesized by the marine diatom Haslea ostrearia (Gaillon/Bory) Simonsen using HPLC gel-filtration and photodiode-array detection, J. Appl, 2006.

. Phycol, , vol.19, pp.263-270

J. Pouvreau, M. Morançais, F. Fleury, P. Rosa, L. Thion et al., Preliminary characterisation of the blue-green pigment "marennine" from the marine tychopelagic diatom Haslea ostrearia (Gaillon/Bory) Simonsen, J. Appl. Phycol, vol.18, pp.757-767, 2006.
URL : https://hal.archives-ouvertes.fr/hal-00412869

J. Pouvreau, M. Morançais, G. Massé, P. Rosa, J. Robert et al., Purification of the blue-green pigment "marennine" from the marine tychopelagic diatom Haslea ostrearia (Gaillon/Bory) Simonsen, J. Appl. Phycol, vol.18, pp.769-781, 2006.

F. S. Prasetiya, L. A. Comeau, R. Gastineau, P. Decottignies, B. Cognie et al., Effect of marennine produced by the blue diatom Haslea ostrearia on behavioral, physiological and biochemical traits of juvenile Mytilus edulis and Crassostrea virginica, Aquaculture, vol.467, pp.138-148, 2017.

,

F. S. Prasetiya, I. Safitri, I. Widowati, B. Cognie, P. Decottignies et al., Does allelopathy affect co-culturing Haslea ostrearia with other microalgae relevant to aquaculture?, J. Appl. Phycol, vol.28, pp.2241-2254, 2016.

,

G. P. Quinn and M. J. Keough, Experimental design and data analysis for biologists, 2002.

G. Ranson, L'absorption de matières organiques dissoutes par la surface extérieure du corps chez les animaux aquatiques, Ann. Inst. Océan, vol.4, p.174, 1927.

J. Robert, M. Morançais, E. Pradier, J. Mouget, and G. Tremblin, Extraction and quantitative analysis of the blue-green pigment "marennine" synthesized by the diatom Haslea ostrearia, 2002.

, Appl. Phycol, vol.14, pp.299-305

L. H. Seychelles, C. Audet, R. Tremblay, K. Lemarchand, and F. Pernet, Bacterial colonization of winter flounder Pseudopleuronectes americanus fed live feed enriched with three different commercial diets, Aquac. Nutr, vol.17, pp.196-206, 2011.

T. Sprat, History of the Royal Society. Martyn, 1667.

R. A. Steinhardt and D. Epel, Activation of Sea-Urchin Eggs by a Calcium Ionophore, Proc. Natl. Acad. Sci, vol.71, pp.1915-1919, 1974.

C. Tardy-laporte, A. A. Arnold, B. Genard, R. Gastineau, M. Morançais et al., A 2H solid-state NMR study of the effect of antimicrobial agents on intact Escherichia coli without mutating, Biochim. Biophys. Acta BBA -Biomembr, vol.1828, pp.614-622, 2013.

,

F. Turcotte, J. Mouget, B. Genard, K. Lemarchand, J. Deschênes et al., Prophylactic effect of Haslea ostrearia culture supernatant containing the pigment marennine to stabilize bivalve hatchery production, Aquat. Living Resour, vol.29, 2016.
URL : https://hal.archives-ouvertes.fr/hal-01613376

V. Turpin, J. Robert, P. Goulletquer, G. Massé, and P. Rosa, Oyster greening by outdoor mass culture of the diatom Haslea ostrearia Simonsen in enriched seawater, Aquac. Res, vol.32, pp.801-809, 2001.

,

T. Wichard, S. A. Poulet, A. L. Boulesteix, J. B. Ledoux, B. Lebreton et al., Influence of diatoms on copepod reproduction. Ii. Uncorrelated effects of diatomderived alpha,beta,gamma,delta-unsaturated aldehydes and, 2008.