The future of high-throughput screening, J Biomol Screen, vol.13, pp.443-451, 2008. ,
Microfluidics: fluid physics at the nanoliter scale, Rev Modern Physics, vol.77, pp.977-1026, 2005. ,
Man-made cell-like compartments for molecular evolution, Nat Biotechnol, vol.16, pp.652-658, 1998. ,
Soft lithography, Annu Rev Mater Sci, vol.28, pp.153-84, 1998. ,
A microfabricated fluorescenceactivated cell sorter, Nat Biotechnol, vol.17, pp.1109-1120, 1999. ,
Microfluidique discrète et biotechnologie, Comptes rendus physique, vol.5, pp.577-88, 2004. ,
Formation of dispersions using « flow focusing » in microchannels, Appl Phys Lett, vol.82, pp.364-370, 2003. ,
Droplet-based microfluidic platforms for the encapsulation and screening of mammalian cells and multicellular organisms, Chem Biol, vol.15, pp.427-464, 2008. ,
URL : https://hal.archives-ouvertes.fr/hal-02148746
An integrated device for monitoring time-dependent in vitro expression from single genes in picolitre droplets, Chembiochem, vol.9, pp.439-485, 2008. ,
A microfluidic system for controlling reaction networks in time, Angew Chem Int Ed, vol.42, pp.768-72, 2003. ,
Electrocoalescence of drops synchronized by size-dependent flow in microfluidic channels, Appl Phys Lett, vol.88, p.29, 2006. ,
Formation of droplets of in microfluidic channels alternating composition and applications to indexing of concentrations in droplet-based assays, Anal Chem, vol.76, pp.4977-82, 2004. ,
Controlled electrocoalescence in microfluidics: Targeting a single lamella, Appl Phys Lett, vol.89, p.134101, 2006. ,
Electric control of droplets in microfluidic devices, Angew Chem Int Ed, vol.45, pp.2556-60, 2006. ,
Droplets as microreactors for highthroughput biology, Chembiochem, vol.8, pp.263-72, 2007. ,
Miniaturizing chemistry and biology in microdroplets, Chem Commun, vol.18, pp.1773-88, 2007. ,
URL : https://hal.archives-ouvertes.fr/hal-02148777
Transforming single DNA molecules into fluorescent magnetic particles for detection and enumeration of genetic variations, Proc Natl Acad Sci, vol.100, pp.8817-8839, 2003. ,
Molecular haplotyping by linking emulsion PCR: analysis of paraoxonase 1 haplotypes and phenotypes, Nucleic Acids Res, vol.33, pp.2615-2624, 2005. ,
PCR amplification from single DNA molecules on magnetic beads in emulsion: application for highthroughput screening of transcription factor targets, Nucleic Acids Res, vol.33, p.150, 2005. ,
Next-generation DNA sequencing methods, Annu Rev Genomics Hum Genet, vol.9, pp.387-402, 2008. ,
On-chip single-copy realtime reverse-transcription PCR in isolated picoliter droplets, Anal Chem, vol.80, pp.1854-1862, 2008. ,
DOI : 10.1021/ac800048k
High-throughput single copy DNA amplification and cell analysis in engineered nanoliter droplets, Anal Chem, vol.80, pp.3522-3531, 2008. ,
High-throughput quantitative polymerase chain reaction in picoliter droplets, Anal Chem, 2009. ,
Millisecond kinetics on a microfluidic chip using nanoliters of reagents, J Am Chem Soc, vol.125, pp.14613-14622, 2003. ,
Reliable microfluidic on-chip incubation of droplets in delay-lines, Lab Chip, p.online, 2009. ,
Reactions in droplets in microfluidic channels, Angew Chem Int Ed, vol.45, pp.7336-56, 2006. ,
Controlling nonspecific protein adsorption in a plug-based microfluidic system by controlling interfacial chemistry using fluorous-phase surfactants, Anal Chem, vol.77, pp.785-96, 2005. ,
Mixing crowded biological solutions in milliseconds, Anal Chem, vol.77, pp.7618-7643, 2005. ,
Monitoring of real-time streptavidin-biotin binding kinetics using droplet microfluidics, Anal Chem, vol.80, pp.7063-7070, 2008. ,
A microfluidic approach for screening submicroliter volumes against multiple reagents by using preformed arrays of nanoliter plugs in a three-phase liquid/liquid/ gas flow, Angew Chem Int Ed, vol.44, pp.2520-2523, 2005. ,
On-chip titration of an anticoagulant argatroban and determination of the clotting time within whole blood or plasma using a plug-based microfluidic system, Anal Chem, vol.78, pp.4839-4888, 2006. ,
, Proc Natl Acad Sci, vol.96, pp.9236-9277, 1999.
Noninvasive prenatal diagnosis of fetal chromosomal aneuploidies by maternal plasma nucleic acid analysis, Clin Chem, vol.54, pp.461-467, 2008. ,
Microfluidic digital PCR enables multigene analysis of individual environmental bacteria, Science, vol.314, pp.1464-1471, 2006. ,
Detection of aneuploidy with digital polymerase chain reaction, Anal Chem, vol.79, pp.7576-7585, 2007. ,
Microfluidics digital PCR reveals a higher than expected fraction of fetal DNA in maternal plasma, Clin Chem, vol.54, pp.1664-72, 2008. ,
Circulating mutant DNA to assess tumor dynamics, Nat Med, vol.14, pp.985-90, 2008. ,
Generation of larger numbers of separated microbial populations by cultivation in segmented-flow microdevices, Lab Chip, vol.3, pp.202-209, 2003. ,
Segmented flow generation by chip reactors for highly parallelized cell cultivation, Biosens Bioelectron, vol.19, pp.1421-1429, 2004. ,
Hydrodynamic micro-encapsulation of aqueous fluids and cells via on the fly photopolymerization, J Micromechanic Microengineer, vol.16, pp.285-91, 2006. ,
Drug discovery: the leading edge, Nature, vol.430, pp.109-124, 2004. ,
Cellular platforms for hts: three case studies, Drug Discov Today, vol.7, pp.353-63, 2002. ,
High-throughput screening of enzyme libraries: in vitro evolution of a beta-galactosidase by fluorescence-activated sorting of double emulsions, Chem Biol, vol.12, pp.1291-300, 2005. ,
Dynamic pattern formation in a vesicle-generating microfluidic device, Phys Rev Lett, vol.86, pp.4163-4169, 2001. ,
Droplet fusion by alternating current (AC) field electrocoalescence in microchannels, Electrophoresis, vol.26, pp.3706-3721, 2005. ,
Geometrically mediated breakup of drops in microfluidic devices, Phys Rev Lett, vol.92, p.6, 2004. ,
From microdroplets to microfluidics: selective emulsion separation in microfluidic devices, Angewandte Chemie-International Edition, vol.47, pp.2042-2047, 2008. ,