COPOLYMERS FOR THE DELIVERY OF DRUGS INTO CELLS

Abstract : Provided is a co-polymer of formula A-B-C or a pharmaceutically acceptable salt thereof, where A comprises a water soluble polymer; B comprises a matrix metalloprotease (MMP)-cleavable polypeptide; C is a chemotherapeutic drug or a derivative thereof; and A is connected to B at a first end through a first covalent bond or a first linking moiety and B is connected to C at a second end through a second covalent bond or a second linking moiety, where the co-polymer is not cross-linked.
Document type :
Patents
Complete list of metadatas

https://hal.archives-ouvertes.fr/hal-02130892
Contributor : Laëtitia Legoupil <>
Submitted on : Thursday, May 16, 2019 - 10:40:01 AM
Last modification on : Thursday, May 16, 2019 - 10:40:01 AM

Identifiers

  • HAL Id : hal-02130892, version 1

Citation

L. Zhu, Federico Perche, Vladimir Torchilin. COPOLYMERS FOR THE DELIVERY OF DRUGS INTO CELLS. France, Patent n° : WO2014085579. 2014. ⟨hal-02130892⟩

Share

Metrics

Record views

5