The expression of c-myb is strongly associated with the presence of estrogen and progesterone receptors in breast cancer

Abstract : The c-myb gene was studied in 112 breast cancers. c-myb and estrogen receptor (ER) transcripts were found in 78 (70%) and 71 (63%) cancers respectively. Of these 71 ER positive cancers, 64 (90%) contained c-myb transcripts and of the 41 ER negative cancers, 27 (66%) did not contain c-myb mRNA. Our data show that c-myb transcripts are strongly associated with ER and progesterone receptors (p less than 10(-4) status in breast cancer. Thus the c-myb expression could be associated with breast cancers of better prognosis and its analysis could allow a better characterization of new subsets of hormono-dependent cancers responding more efficiently to hormonotherapy.
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Submitted on : Monday, May 13, 2019 - 3:27:11 PM
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  • HAL Id : hal-02127559, version 1
  • PUBMED : 2907731

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Martine Guerin, M. Barrois, G Riou. The expression of c-myb is strongly associated with the presence of estrogen and progesterone receptors in breast cancer. Comptes rendus de l’Académie des sciences. Série III, Sciences de la vie, Elsevier, 1988, 307 (20), pp.855-61. ⟨hal-02127559⟩

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