Krystel El Hage, Jean-Philip Piquemal, Nassima Oumata, Laurent Meijer, Hervé Galons, et al.. A Simple Isomerization of the Purine Scaffold of a Kinase Inhibitor, Roscovitine, Affords a Four- to Seven-Fold Enhancement of Its Affinity for Four CDKs. Could This Be Traced Back to Conjugation-Induced Stiffenings/Loosenings of Rotational Barriers?.
ACS Omega, ACS Publications, 2017, 2 (7), pp.3467-3474.
⟨10.1021/acsomega.7b00471⟩.
⟨hal-02126840⟩