New functional domains of human cytomegalovirus pUL89 predicted by sequence analysis and three-dimensional modelling of the catalytic site DEXDc.

Gaël Champier 1 Sébastien Hantz 1 Anthony Couvreux 2 Stéphanie Stuppfler Marie-Christine Mazeron 3 Serge Bouaziz 4 François Denis 5 Sophie Alain 2
1 EA3175 - Biologie moléculaire et cellulaire des microorganismes
2 Service de Bactériologie, Virologie, Hygiène [CHU Limoges]
3 Hôpital Lariboisière
4 UPCG - UMR_S 640/UMR 8151 - Unité de Pharmacologie Chimique et Génétique
5 LIF - Laboratoire d'informatique Fondamentale de Marseille - UMR 6166
Abstract : Benzimidazole D-ribonucleosides inhibit DNA packaging during human cytomegalovirus (HCMV) replication. Although they have been shown to target pUL56 and pUL89, the large and small subunits of the HCMV terminase respectively, their mechanism of action is not yet fully understood.
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Journal articles
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https://hal.archives-ouvertes.fr/hal-02122527
Contributor : Serge Bouaziz <>
Submitted on : Tuesday, May 7, 2019 - 2:03:40 PM
Last modification on : Thursday, May 9, 2019 - 2:48:08 PM

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  • HAL Id : hal-02122527, version 1
  • PUBMED : 17503664

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UPCG | IFR71 | UNILIM | ENSCP | LIF | CNRS | UMR-S1092 | PSL | UNIV-PARIS5 | LIS-LAB | GEIST | UNIV-AMU | PARISTECH | UNIV-PARIS7 | USPC

Citation

Gaël Champier, Sébastien Hantz, Anthony Couvreux, Stéphanie Stuppfler, Marie-Christine Mazeron, et al.. New functional domains of human cytomegalovirus pUL89 predicted by sequence analysis and three-dimensional modelling of the catalytic site DEXDc.. Antiviral Therapy, International Medical Press, 2019, 12 (2), pp.217-32. ⟨hal-02122527⟩

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