Putative functional domains of human cytomegalovirus pUL56 involved in dimerization and benzimidazole D-ribonucleoside activity.

Abstract : Benzimidazole D-ribonucleosides inhibit DNA packaging during human cytomegalovirus (HCMV) replication. Although they have been shown to target pUL56 and pUL89 (the large and small subunits of the HCMV terminase, respectively) their mechanism of action is not yet fully understood. We aimed here to better understand HCMV DNA maturation and the mechanism of action of benzimidazole derivatives.
Document type :
Journal articles
Complete list of metadatas

https://hal.archives-ouvertes.fr/hal-02122512
Contributor : Serge Bouaziz <>
Submitted on : Tuesday, May 7, 2019 - 1:58:56 PM
Last modification on : Thursday, May 9, 2019 - 2:48:08 PM

Identifiers

  • HAL Id : hal-02122512, version 1
  • PUBMED : 18771048

Citation

Gaël Champier, Anthony Couvreux, Sébastien Hantz, Armelle Rametti, Marie-Christine Mazeron, et al.. Putative functional domains of human cytomegalovirus pUL56 involved in dimerization and benzimidazole D-ribonucleoside activity.. Antiviral Therapy, International Medical Press, 2019, 13 (5), pp.643-54. ⟨hal-02122512⟩

Share

Metrics

Record views

37