Conserved domains and structure prediction of human cytomegalovirus UL27 protein.

Abstract : The human cytomegalovirus (HCMV) nuclear UL27 protein (pUL27) could be involved at the stage of nuclear egress. Maribavir is a new anti-HCMV drug that targets nuclear egress through direct inhibition of the HCMV serine-threonine kinase, UL97 protein (pUL97). Because maribavir-resistance-related mutations are observed in both proteins, pUL27 is thought to interfere with pUL97 activity; however, its mechanism of action remains unclear.
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https://hal.archives-ouvertes.fr/hal-02122495
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Submitted on : Tuesday, May 7, 2019 - 1:53:25 PM
Last modification on : Thursday, May 9, 2019 - 2:48:08 PM

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  • HAL Id : hal-02122495, version 1
  • PUBMED : 19704169

Citation

Sébastien Hantz, Anthony Couvreux, Gaël Champier, Laurène Trapes, Sébastien Cotin, et al.. Conserved domains and structure prediction of human cytomegalovirus UL27 protein.. Antiviral Therapy, International Medical Press, 2019, 14 (5), pp.663-72. ⟨hal-02122495⟩

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