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Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity

Abstract : Natural products guttiferone A, hyperforin, and aristoforin were able to inhibit or increase SIRT1 catalytic activity, depending on protein concentration and presence of detergent. On the basis of NMR data for guttiferone A, we demonstrated that the aggregation state of the natural product played a crucial role for its interaction with the enzyme. These results are useful to interpret future in vitro structure-activity relationship studies on these natural products in the quest of their biological target(s).
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https://hal.archives-ouvertes.fr/hal-02122343
Contributor : Serge Bouaziz Connect in order to contact the contributor
Submitted on : Tuesday, May 7, 2019 - 11:54:35 AM
Last modification on : Wednesday, December 15, 2021 - 11:18:08 AM

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Kévin Cottet, Bin Xu, Pascale Coric, Serge Bouaziz, Michel Michel, et al.. Guttiferone A Aggregates Modulate Silent Information Regulator 1 (SIRT1) Activity. Journal of Medicinal Chemistry, American Chemical Society, 2016, 59 (20), pp.9560-9566. ⟨10.1021/acs.jmedchem.6b01182⟩. ⟨hal-02122343⟩

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