Nucleomimetic strategy for the inhibition of HIV-1 nucleocapsid protein NCp7 activities.

S Druillennec (1) , H Meudal (1) , B.P Roques , M.C Fournié-Zaluski

1 Pharmacochimie moléculaire et structurale

We report the synthesis and biological properties of three modified dinucleotides T*G, G*T and T*T in which the natural phosphodiester linkage has been replaced by a methylene carboxamide unit. They have been designed to act as nucleomimetics of a sequence recognized by the HIV-1 nucleocapsid protein NCp7 and to inhibit this interaction.

Domaines: Sciences du Vivant [q-bio]

S Druillennec, H Meudal, B.P Roques, M.C Fournié-Zaluski. Nucleomimetic strategy for the inhibition of HIV-1 nucleocapsid protein NCp7 activities.. Bioorganic and Medicinal Chemistry Letters, 1999, 9 (4), pp.627-32. ⟨hal-02122144⟩