Novel constrained CCK-B dipeptoid antagonists derived from pipecolic acid.

Abstract : A new series of 4-substituted pipecolic acid derivatives was prepared and incorporated into dipeptoids. The resulting products behave as moderately potent CCK-B antagonists but their constrained structure and its comparison with structurally related compounds yield valuable information about the conformational requirements for optimal recognition of the CCK-B receptor by antagonists.
Document type :
Journal articles
Complete list of metadatas

https://hal.archives-ouvertes.fr/hal-02122133
Contributor : Laëtitia Legoupil <>
Submitted on : Tuesday, May 7, 2019 - 10:15:43 AM
Last modification on : Monday, June 3, 2019 - 5:08:22 PM

Identifiers

  • HAL Id : hal-02122133, version 1
  • PUBMED : 9871777

Collections

Citation

B Bellier, S Da Nascimento, H. Meudal, E. Gincel, B.P Roques, et al.. Novel constrained CCK-B dipeptoid antagonists derived from pipecolic acid.. Bioorganic and Medicinal Chemistry Letters, Elsevier, 1998, 8 (11), pp.1419-24. ⟨hal-02122133⟩

Share

Metrics

Record views

19