Th1 cell development induced by cysteine proteinases A and B in localized cutaneous leishmaniasis due to Leishmania guyanensis.

Hervé Pascalis (1) , Pascal Pascalis , Anne Lavergne (1) , Eliane Bourreau (1) , Ghislaine Prévot-Linguet , Amina Kariminia , Roger Pradinaud (2) , Sima Rafati (3) , Pascal Launois (1)

1 Institut Pasteur de la Guyane
2 Centre Hospitalier Andrée Rosemon [Cayenne, Guyane Française]
3 Institut Pasteur d'Iran

The cysteine proteinases CPA and CPB from Leishmania major induced Th1 responses in patients with leishmaniasis due to Leishmania guyanensis. Furthermore, cysteine proteinases induced neither interleukin 4 (IL-4) nor IL-13 and low levels of IL-10 in controls and patients. The results suggest that CPs would be quite good candidates for a vaccine against different Leishmania species.

Domaines: Sciences du Vivant [q-bio]; Immunologie; Microbiologie et Parasitologie; Parasitologie; Médecine humaine et pathologie

Hervé Pascalis, Pascal Pascalis, Anne Lavergne, Eliane Bourreau, Ghislaine Prévot-Linguet, et al.. Th1 cell development induced by cysteine proteinases A and B in localized cutaneous leishmaniasis due to Leishmania guyanensis.. Infection and Immunity, 2003, 71 (5), pp.2924-6. ⟨10.1128/IAI.71.5.2924-2926.2003⟩. ⟨hal-02116562⟩