Fabrication and characterization of hardystonite-chitosan biocomposite scaffolds

Silvia Stella Ramirez Caballero (1, 2) , Hamada Elsayed (3, 4) , Solene Tadier (1) , Alexandra Montembault (2) , Eric Maire (1) , Laurent David (2) , Thierry Delair (2) , Paolo Colombo (3, 5) , Laurent Gremillard (1)

1 MATEIS - Matériaux, ingénierie et science [Villeurbanne]
2 IMP-LMPB - Ingénierie des Matériaux Polymères - Laboratoire des Matériaux Polymères et des Biomatériaux
3 Department of Industrial Engineering [Padova]
4 Ceramics Department, National Research Centre
5 Penn State - Pennsylvania State University

Hardystonite scaffolds produced by ceramization of 3-D printed preceramic filled polymer were impregnated with chitosan solutions, later neutralized into physical hydrogels. Hardystonite bioceramic and chitosan physical hydrogel were chosen for their interesting biological properties as potential bone substitutes. Five impregnation protocols, differing in impregnation vacuum, chitosan concentration, chitosan to hardystonite mass ratio and base used for chitosan gelation were studied. The composition, micropore structure and surface morphology of impregnated scaffolds were determined. Impregnated hardystonite scaffolds were tested to find out the effect of impregnation protocols on elastic and dissipative mechanical properties of the composites. The capacity for energy dissipation and for load bearing increased as chitosan content increased in the composites. Thus, 3-D architectured biocomposites with enhanced mechanical properties can be manufactured following the method shown in this article.

Mots clés: Direct ink writing; Physical hydrogels; Polymer impregnation; Bone substitutes; Ceramic-polymer composites; Fracture

Domaines: Matériaux

Silvia Stella Ramirez Caballero, Hamada Elsayed, Solene Tadier, Alexandra Montembault, Eric Maire, et al.. Fabrication and characterization of hardystonite-chitosan biocomposite scaffolds. Ceramics International, 2019, 45 (7), pp.8804-8814. ⟨10.1016/j.ceramint.2019.01.206⟩. ⟨hal-02115206⟩