Biorthogonal click chemistry on poly(lactic-co-glycolic acid)-polymeric particles

Abstract : Biodegradable polymeric materials are a key area of investigation in drug delivery and disease treatment. This is due to their proven clinical potential for payload protection, responsivity, and surface modification imparted by the versatile array of polymers available for their formulation. Here, we employ a novel biodegradable azide containing polymer in the formulation of polymeric nanoparticles and show that these particles can then be functionalized, with biorthogonal click reactions, to alter their surface appearance and their ability to interact with biological systems.
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https://hal.archives-ouvertes.fr/hal-02111568
Contributor : Laëtitia Legoupil <>
Submitted on : Friday, April 26, 2019 - 10:03:38 AM
Last modification on : Friday, April 26, 2019 - 10:03:38 AM

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Jason Olejniczak, Guillaume Collet, Viet Anh Nguyen Huu, Minnie Chan, Sangeun Lee, et al.. Biorthogonal click chemistry on poly(lactic-co-glycolic acid)-polymeric particles. Biomaterials Science, Royal Society of Chemistry (RSC), 2017, 5 (2), pp.211-215. ⟨10.1039/C6BM00721J⟩. ⟨hal-02111568⟩

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