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Article Dans Une Revue Journal of Nutritional Biochemistry Année : 2019

A mix of dietary fermentable fibers improves lipids handling by the liver of overfed minipigs

Ahmed Ben Mohamed
  • Fonction : Auteur correspondant
Didier Remond
Christophe Chambon
Thierry Sayd
  • Fonction : Auteur
  • PersonId : 1204832
Frédéric Capel
Benoit Cohade
  • Fonction : Auteur
  • PersonId : 1204597
Noureddine Hafnaoui
  • Fonction : Auteur
  • PersonId : 1207186
Daniel Béchet
Cécile Coudy-Gandilhon
  • Fonction : Auteur
  • PersonId : 1205595
Carole Migné
Jérémie David
  • Fonction : Auteur
  • PersonId : 1204399
Dominique Dardevet
Sergio Polakof

Résumé

Obesity induced by overfeeding ultimately can lead to nonalcoholic fatty liver disease, whereas dietary fiber consumption is known to have a beneficial effect. We aimed to determine if a supplementation of a mix of fibers (inulin, resistant starch and pectin) could limit or alleviate overfeeding-induced metabolic perturbations. Twenty female minipigs were fed with a control diet (C) or an enriched fat/sucrose diet supplemented (O + F) or not (O) with fibers. Between 0 and 56 days of overfeeding, insulin (+88%), HOMA (+102%), cholesterol (+45%) and lactate (+63%) were increased, without any beneficial effect of fibers supplementation. However, fibers supplementation limited body weight gain (vs. O, −15% at D56) and the accumulation of hepatic lipids droplets induced by overfeeding. This could be explained by a decreased lipids transport potential (−50% FABP1 mRNA, O + F vs. O) inducing a down-regulation of regulatory elements of lipids metabolism / lipogenesis (−36% SREBP1c mRNA, O + F vs. O) but not to an increased oxidation (O + F not different from O and C for proteins and mRNA measured). Glucose metabolism was also differentially regulated by fibers supplementation, with an increased net hepatic release of glucose in the fasted state (diet × time effect, P<.05 at D56) that can be explained partially by a possible increased glycogen synthesis in the fed state (+82% GYS2 protein, O + F vs. O, P=.09). The direct role of short chain fatty acids on gluconeogenesis stimulation is questioned, with probably a short-term impact (D14) but no effect on a long-term (D56) basis.
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Dates et versions

hal-02101573 , version 1 (16-04-2019)

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Paternité - Pas d'utilisation commerciale - Pas de modification

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Citer

Ahmed Ben Mohamed, Didier Remond, Christophe Chambon, Thierry Sayd, Michel Hébraud, et al.. A mix of dietary fermentable fibers improves lipids handling by the liver of overfed minipigs. Journal of Nutritional Biochemistry, 2019, 65, pp.72-82. ⟨10.1016/j.jnutbio.2018.12.002⟩. ⟨hal-02101573⟩
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