Multimodal Outcome at 7 Years of Age after Neonatal Arterial Ischemic Stroke

Stéphane Chabrier (1) , Emeline Peyric (1) , Laure Drutel (1) , Johanna Deron (1) , Manoelle Kossorotoff (2) , Mickaël Dinomais (3) , Leila Lazaro (4) , Jérémie Lefranc (5) , Guillaume Thébault (6) , Gérard Dray (7) , Joel Fluss (8) , Cyrille Renaud (9) , Sylvie Nguyen The Tich (3)

1 CIC-EC 1408 - Centre d'Investigation Clinique - Epidémiologie Clinique [CHU Saint-Etienne]
2 Service de neurologie pédiatrique [CHU Necker]
3 LARIS - Laboratoire Angevin de Recherche en Ingénierie des Systèmes
4 CHCB - Centre Hospitalier de la Côte Basque
5 CHU BREST Pédiatrie - CHRU de Brest - Département de Pédiatrie
6 EPSYLON - Dynamique des capacités humaines et des conduites de santé
7 LGI2P - Laboratoire de Génie Informatique et Ingénierie de Production
8 HUG - Geneva University Hospital
9 GRT - Groupe de recherche sur la thrombose, pharmacologie des antithrombotiques et situations à risque

Objectives: To evaluate the epileptic, academic, and developmental status at age 7 years in a large population of term-born children who sustained neonatal arterial ischemic stroke (NAIS), and to assess the co-occurrence of these outcomes. Study design: A cohort study including 100 term newborns with NAIS was designed. Two infants died during the neonatal period, 13 families were lost to follow-up, and 5 families declined to participate in this evaluation. Thus, 80 families completed the 7-year clinical assessment. Epileptic status, schooling, motor abilities, global intellectual functioning, spoken language, and parental opinions were recorded. Principal component analysis was applied. Results: Rates of impaired language, cerebral palsy, low academic skills, active epilepsy, and global intellectual deficiency were 49%, 32%, 28%, 11%, and 8%, respectively. All were highly correlated. Eventually, 59% of children were affected by at least 1 of the aforementioned conditions. In 30% of cases, the viewpoints of health practitioners and parents did not match. Conclusion: The prevalence of severe disabilities at 7 years after NAIS is low, but most children exhibit some impairment in developmental profile.

Domaines: Pédiatrie; Neurosciences [q-bio.NC]; Santé publique et épidémiologie

Stéphane Chabrier, Emeline Peyric, Laure Drutel, Johanna Deron, Manoelle Kossorotoff, et al.. Multimodal Outcome at 7 Years of Age after Neonatal Arterial Ischemic Stroke. The Journal of Pediatrics, 2016, 172, pp.156-161.e3. ⟨10.1016/j.jpeds.2016.01.069⟩. ⟨hal-02099375⟩