Targeted Radionuclide Therapy Using a Wnt-Targeted Replicating Adenovirus Encoding the Na/I Symporter

Abstract : The Na/I symporter (hNIS) promotes concentration of iodine in cells. In cancer gene therapy, this transgene has potential as a reporter gene for molecular imaging of viral biodistribution and as a therapeutic protein promoting (131)I-mediated radiotherapy. Here, we combined the imaging and therapeutic potential of hNIS in an oncolytic adenoviruses targeting colorectal cancer cells.
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https://hal.archives-ouvertes.fr/hal-02086310
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Submitted on : Monday, April 1, 2019 - 11:59:44 AM
Last modification on : Tuesday, May 14, 2019 - 2:42:06 PM

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Inge Peerlinck, Andrew Merron, Patrick Baril, Sophie Conchon, Pilar Martin-Duque, et al.. Targeted Radionuclide Therapy Using a Wnt-Targeted Replicating Adenovirus Encoding the Na/I Symporter. Clinical Cancer Research, American Association for Cancer Research, 2009, 15 (21), pp.6595-6601. ⟨10.1158/1078-0432.CCR-09-0262⟩. ⟨hal-02086310⟩

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