Targeted Radionuclide Therapy Using a Wnt-Targeted Replicating Adenovirus Encoding the Na/I Symporter

Inge Peerlinck , Andrew Merron , Patrick Baril (1) , Sophie Conchon (2) , Pilar Martin-Duque , Cecilia Hindorf , Jerome Burnet , Miguel Quintanilla , Mohan Hingorani , Richard Iggo , Nr Lemoine , Kevin Harrington , Georges Vassaux

1 CBM - Centre de biophysique moléculaire
2 U1064 Inserm - CRTI - Centre de Recherche en Transplantation et Immunologie

The Na/I symporter (hNIS) promotes concentration of iodine in cells. In cancer gene therapy, this transgene has potential as a reporter gene for molecular imaging of viral biodistribution and as a therapeutic protein promoting (131)I-mediated radiotherapy. Here, we combined the imaging and therapeutic potential of hNIS in an oncolytic adenoviruses targeting colorectal cancer cells.

Domaines: Sciences du Vivant [q-bio]

Inge Peerlinck, Andrew Merron, Patrick Baril, Sophie Conchon, Pilar Martin-Duque, et al.. Targeted Radionuclide Therapy Using a Wnt-Targeted Replicating Adenovirus Encoding the Na/I Symporter. Clinical Cancer Research, 2009, 15 (21), pp.6595-6601. ⟨10.1158/1078-0432.CCR-09-0262⟩. ⟨hal-02086310⟩