Assessment of the Na/I symporter as a reporter gene to visualize oncolytic adenovirus propagation in peritoneal tumours

Andrew Merron (1) , Patrick Baril (2) , Pilar Martin-Duque , Antonio de La Vieja , Lucile Tran , Arnaud Briat , Kevin Harrington , Iain Mcneish , Georges Vassaux

1 Centre for Molecular Oncology and Imaging
2 CBM - Centre de biophysique moléculaire

In vivo imaging of the spread of oncolytic viruses using the Na/I symporter (NIS) has been proposed. Here, we assessed whether the presence of NIS in the viral genome affects the therapeutic efficacy of the oncolytic adenovirus dl922-947 following intraperitoneal administration, in a mouse model of peritoneal ovarian carcinoma.

Domaines: Sciences du Vivant [q-bio]

Andrew Merron, Patrick Baril, Pilar Martin-Duque, Antonio de La Vieja, Lucile Tran, et al.. Assessment of the Na/I symporter as a reporter gene to visualize oncolytic adenovirus propagation in peritoneal tumours. European Journal of Nuclear Medicine and Molecular Imaging, 2010, 37 (7), pp.1377-1385. ⟨10.1007/s00259-009-1379-3⟩. ⟨hal-02086304⟩