Particles Comprising Luminescent Lanthanide Complexes

Abstract : The present invention relates to particles, useful for drug release detection, comprising: at least one luminescent metal complex of formula [Ln].[L], wherein: Ln is a lanthanide ion, L is an organic ligand comprising a hydrophilic unit with at least 6 chelating groups chosen from the group consisting of hydroxyl, carboxyl, optionally in the carboxylate form, carbonyl, ether, phosphonate, phosphinate, thiolate, amino and imino functions, and - at least one drug comprising a conjugated aromatic system, wherein said drug is not covalently bonded to the metal complex, said particle having a size comprised from 3 nm to 2 000 nm, and wherein the distribution of the metal complex and the drug within the particle is such that the mean distance between a drug molecule and a metal complex is less than 15 nm.
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https://hal.archives-ouvertes.fr/hal-02081138
Contributor : Laëtitia Legoupil <>
Submitted on : Wednesday, March 27, 2019 - 12:19:47 PM
Last modification on : Thursday, May 2, 2019 - 3:20:07 PM

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  • HAL Id : hal-02081138, version 1

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Éva Tóth, Stephane Petoud, Célia Bonnet, S. Lacerda. Particles Comprising Luminescent Lanthanide Complexes. France, Patent n° : 13305291.0. 2014. ⟨hal-02081138⟩

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