Roles of LIM kinases in central nervous system function and dysfunction

H. Cuberos , B. Vallée (1) , P. Vourc'H (2) , J. Tastet , C.R. Andres (2) , H. Bénédetti (1)

1 CBM - Centre de biophysique moléculaire
2 iBraiN - Imaging, Brain & Neuropsychiatry

We finally present the existence of a cofilin-independent pathway also involved in neuronal function. A better understanding of the differences between both LIMKs and of the precise molecular mechanisms involved in their mode of action and regulation is now required to improve our understanding of the physiopathology of the neuronal diseases associated with LIMKs.

Domaines: Sciences du Vivant [q-bio]

H. Cuberos, B. Vallée, P. Vourc'H, J. Tastet, C.R. Andres, et al.. Roles of LIM kinases in central nervous system function and dysfunction. FEBS Letters, 2015, 589 (24PartB), pp.3795-3806. ⟨10.1016/j.febslet.2015.10.032⟩. ⟨hal-02072231⟩