Le système histaminergique : une cible pour de nouveaux traitements des deficits cognitifs

Abstract : The central effects of histamine are mediated by H1,H2 and H3 receptors. The H3 receptor inhibits histamine release in brain. Therefore, H3 receptor inverse agonists, by suppressing this brake, enhance histamine neuron activity. The histaminergic system plays a major role in cognition and H3 receptor inverse agonists are expected to be a potential therapeutics for cognitive deficits of Alzheimer’s disease (AD). They are eagerly awaited inasmuch as other treatments of the disease, such as tacrine or memantine, also enhance, through different mechanisms, histaminergic neurotransmission. An important loss of histaminergic neurons has been observed in AD. In contrast, levels of the histamine metabolite in the CSF of AD patients show that their global activity is decreased by only 25%. This indicates that activating histamine neurons in AD can be envisaged.
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Submitted on : Monday, March 18, 2019 - 2:33:17 PM
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Mouhammad Motawaj, Aude Burban, Elisabeth Davenas, Florence Gbahou, Raphaël Faucard, et al.. Le système histaminergique : une cible pour de nouveaux traitements des deficits cognitifs. Thérapie, EDP Sciences, 2010, 65 (5), pp.415-422. ⟨10.2515/therapie/2010058⟩. ⟨hal-02071208⟩

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