Sonoporation: Mechanistic insights and ongoing challenges for gene transfer

Abstract : Microbubbles first developed as ultrasound contrast agents have been used to assist ultrasound for cellular drug and gene delivery. Their oscillation behavior during ultrasound exposure leads to transient membrane permeability of surrounding cells, facilitating targeted local delivery. The increased cell uptake of extracellular compounds by ultrasound in the presence of microbubbles is attributed to a phenomenon called sonoporation. In this review, we summarize current state of the art concerning microbubble-cell interactions and cellular effects leading to sonoporation and its application for gene delivery. Optimization of sonoporation protocol and composition of microbubbles for gene delivery are discussed.
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https://hal.archives-ouvertes.fr/hal-02070788
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Submitted on : Monday, March 18, 2019 - 11:32:55 AM
Last modification on : Thursday, June 20, 2019 - 12:22:09 PM

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Anthony Delalande, Spiros Kotopoulis, Michiel Postema, Patrick Midoux, Chantal Pichon. Sonoporation: Mechanistic insights and ongoing challenges for gene transfer. Gene, Elsevier, 2013, 525 (2), pp.191-199. ⟨10.1016/j.gene.2013.03.095⟩. ⟨hal-02070788⟩

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