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Antibiotic R2, a new angucyclinone compound from Streptosporangium sp. Sg3

Abstract : Angucyclinones are a subclass of angucyclines, which are defined as microbial quinone natural products related to tetracyclines and anthracyclines and bearing, as characteristic structural feature, a tetracyclic benz[a]anthracene ring system assembled in an angular manner. This structural moiety is biosynthetically derived from a decaketide chain formed via the polyketide biosynthetic pathway. The term ‘angucycline’ includes molecules with hydrolysable sugar moieties, whereas ‘angucyclinone’ refers to a sugarless compound or a compound with a C-glycosidic linked sugar moiety. Angucyclines are isolated from the fermentation broth of actinomycetes, mostly from the genus Streptomyces, but also from Actinomadura, Nocardia and Streptosporangium genera.1 Angucyclines show a broad spectrum of biological activities including antitumor, antibacterial, antifungal, antiviral, enzyme inhibitory and platelet aggregation inhibitory properties. In a continuous search for new bioactive compounds from actinomycetes other than the genus Streptomyces, several Saharan soil samples collected in arid ecosystems were explored. Among the isolates, we were interested by a new actinomycete strain belonging to the genus Streptosporangium and producing a new compound (R2) identified as a new angucyclinone. This paper describes the isolation, structure elucidation and antimicrobial activities of compound R2.
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Hadjira Boudjella, Abdelghani Zitouni, Yannick Coppel, Florence Mathieu, Marie-Carmen Monje, et al.. Antibiotic R2, a new angucyclinone compound from Streptosporangium sp. Sg3. Journal of Antibiotics, Nature Publishing Group: Open Access Hybrid Model Option B, 2010, 63 (12), pp.709-711. ⟨10.1038/ja.2010.111⟩. ⟨hal-02066622⟩



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