Rapid detection and discrimination of chromosome- and MCR-plasmid-mediated resistance to polymyxins by MALDI-TOF MS in Escherichia coli: the MALDIxin test - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue Journal of Antimicrobial Chemotherapy Année : 2018

Rapid detection and discrimination of chromosome- and MCR-plasmid-mediated resistance to polymyxins by MALDI-TOF MS in Escherichia coli: the MALDIxin test

Ivana Pennisi
  • Fonction : Auteur
Laura Gauthier
  • Fonction : Auteur
Laura Dabos
  • Fonction : Auteur
R Christopher D Furniss
  • Fonction : Auteur
Despoina Mavridou
  • Fonction : Auteur
Pierre Bogaerts
  • Fonction : Auteur
Frédéric Robin
Thierry Naas
  • Fonction : Auteur
  • PersonId : 889340

Résumé

Polymyxins are currently considered a last-resort treatment for infections caused by MDR Gram-negative bacteria. Recently, the emergence of carbapenemase-producing Enterobacteriaceae has accelerated the use of polymyxins in the clinic, resulting in an increase in polymyxin-resistant bacteria. Polymyxin resistance arises through modification of lipid A, such as the addition of phosphoethanolamine (pETN). The underlying mechanisms involve numerous chromosome-encoded genes or, more worryingly, a plasmid-encoded pETN transferase named MCR. Currently, detection of polymyxin resistance is difficult and time consuming.

Dates et versions

hal-02064649 , version 1 (12-03-2019)

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Citer

Laurent Dortet, Rémy Bonnin, Ivana Pennisi, Laura Gauthier, Agnès Jousset, et al.. Rapid detection and discrimination of chromosome- and MCR-plasmid-mediated resistance to polymyxins by MALDI-TOF MS in Escherichia coli: the MALDIxin test. Journal of Antimicrobial Chemotherapy, 2018, 73 (12), pp.3359-3367. ⟨10.1093/jac/dky330⟩. ⟨hal-02064649⟩
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