A Novel Online Four-Dimensional SEC×SEC-IM×MS Methodology for Characterization of Monoclonal Antibody Size Variants

Anthony Ehkirch (1) , Alexandre Goyon (2) , Oscar Hernandez-Alba (1) , Florent Rouvière (3) , Valentina D’atri (2) , Cyrille Dreyfus (4) , Jean-François Haeuw (4) , Hélène Diemer (1) , Alain Beck (4) , Sabine Heinisch (3) , Davy Guillarme (2) , Sarah Cianférani (1)

1 IPHC - Institut Pluridisciplinaire Hubert Curien
2 School of Pharmaceutical Science
3 ISA-Chromatography & Hyphenated Techniques - Chromatographie et techniques couplées
4 CIPF - Centre d'Immunologie Pierre Fabre

Domaines: Chimie analytique

Anthony Ehkirch, Alexandre Goyon, Oscar Hernandez-Alba, Florent Rouvière, Valentina D’atri, et al.. A Novel Online Four-Dimensional SEC×SEC-IM×MS Methodology for Characterization of Monoclonal Antibody Size Variants. Analytical Chemistry, 2018, 90 (23), pp.13929-13937. ⟨10.1021/acs.analchem.8b03333⟩. ⟨hal-02060860⟩