A novel synaptic plasticity rule explains homeostasis of neuromuscular transmission - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue eLife Année : 2016

A novel synaptic plasticity rule explains homeostasis of neuromuscular transmission

A novel synaptic plasticity rule explains homeostasis of neuromuscular transmission.

Résumé

Excitability differs among muscle fibers and undergoes continuous changes during development and growth, yet the neuromuscular synapse maintains a remarkable fidelity of execution. Here we show in two evolutionarily distant vertebrates (Xenopus laevis cell culture and mouse nerve-muscle ex-vivo) that the skeletal muscle cell constantly senses, through two identified calcium signals, synaptic events and their efficacy in eliciting spikes. These sensors trigger retrograde signal(s) that control presynaptic neurotransmitter release, resulting in synaptic potentiation or depression. In the absence of spikes, synaptic events trigger potentiation. Once the synapse is sufficiently strong to initiate spiking, the occurrence of these spikes activates a negative retrograde feedback. These opposing signals dynamically balance the synapse in order to continuously adjust neurotransmitter release to a level matching current muscle cell excitability.

Dates et versions

hal-02060598 , version 1 (07-03-2019)

Identifiants

Citer

Gilles Ouanounou, Gérard Baux, Thierry Bal. A novel synaptic plasticity rule explains homeostasis of neuromuscular transmission. eLife, 2016, 5, ⟨10.7554/eLife.12190⟩. ⟨hal-02060598⟩
27 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More