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Impact of cerebral blood flow level on the fluctuations of resting-state BOLD fMRI in anesthetized rats

Abstract : The Blood Oxygen Level Dependent (BOLD) signal, used in resting-state functional Magnetic Resonance Imaging (fMRI), is tighly linked to Cerebral Blood Flow (CBF). This study evaluates the impact of the CBF on the low-frequencies BOLD fluctuations and four physiological parameters during resting state in 5 groups of rats (Wistar and Long-Evans) anesthetized with Isoflurane, Medetomidine, Etomidate and Urethane. It is shown that the CBF is not related to physiological parameters, and there exists a range of CBF values where the BOLD fluctations are sufficiently high for being used in any other analysis.
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https://hal.archives-ouvertes.fr/hal-02059352
Contributor : Guillaume Becq <>
Submitted on : Wednesday, March 6, 2019 - 3:18:02 PM
Last modification on : Thursday, May 20, 2021 - 4:50:03 PM
Long-term archiving on: : Friday, June 7, 2019 - 7:09:17 PM

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  • HAL Id : hal-02059352, version 2

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Sophie Achard, Guillaume Becq, Tarik Habet, Nora Collomb, Margaux Faucher, et al.. Impact of cerebral blood flow level on the fluctuations of resting-state BOLD fMRI in anesthetized rats. Joint Annual Meeting ISMRM-ESMRMB 2018, Jun 2018, Paris, France. ⟨hal-02059352v2⟩

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