Impact of cerebral blood flow level on the fluctuations of resting-state BOLD fMRI in anesthetized rats

Sophie Achard (1) , Guillaume Jean-Paul Claude Becq (2, 3) , Tarik Habet (4) , Nora Collomb (4) , Margaux Faucher (4) , Chantal Delon-Martin (5) , Véronique Coizet (6) , Emmanuel L. Barbier (7)

1 GIPSA-VIBS - GIPSA - Vision and Brain Signal Processing
2 GIPSA-Services - GIPSA-Services
3 GIPSA-CICS - GIPSA - Communication Information and Complex Systems
4 GIN - [GIN] Grenoble Institut des Neurosciences
5 Neuroimagerie Fonctionnelle et Metabolique
6 INSERM U836, équipe 10, Dynamique des réseaux neuronaux du mouvement
7 INSERM U836, équipe 5, Neuro-imagerie fonctionnelle et métabolique

The Blood Oxygen Level Dependent (BOLD) signal, used in resting-state functional Magnetic Resonance Imaging (fMRI), is tighly linked to Cerebral Blood Flow (CBF). This study evaluates the impact of the CBF on the low-frequencies BOLD fluctuations and four physiological parameters during resting state in 5 groups of rats (Wistar and Long-Evans) anesthetized with Isoflurane, Medetomidine, Etomidate and Urethane. It is shown that the CBF is not related to physiological parameters, and there exists a range of CBF values where the BOLD fluctations are sufficiently high for being used in any other analysis.

Domaines: Médecine nucléaire; Traitement du signal et de l'image [eess.SP]; Neurobiologie; Médecine vétérinaire et santé animale

Sophie Achard, Guillaume Jean-Paul Claude Becq, Tarik Habet, Nora Collomb, Margaux Faucher, et al.. Impact of cerebral blood flow level on the fluctuations of resting-state BOLD fMRI in anesthetized rats. Joint Annual Meeting ISMRM-ESMRMB 2018, Jun 2018, Paris, France. ⟨hal-02059352v2⟩