A multicenter randomized controlled trial of a 3-L/kg/min versus 2-L/kg/min high-flow nasal cannula flow rate in young infants with severe viral bronchiolitis (TRAMONTANE 2)

Christophe Milesi (1) , Anne-Florence Pierre , Anna Deho , Robin Pouyau , Jean-Michel Liet , Camille Guillot , Anne-Sophie Guilbert , Jérôme Rambaud , Astrid Millet , Mickael Afanetti , Julie Guichoux , Mathieu Genuini , Thierry Mansir , Jean Bergounioux , Fabrice Michel , Marie-Odile Marcoux , Julien Baleine (1) , Sabine Durand (1) , Philippe Durand , Stéphane Dauger , Etienne Javouhey (2) , Stéphane Leteurtre , Olivier Brissaud , Sylvain Renolleau , Aurélie Portefaix , Aymeric Douillard (1) , Gilles Cambonie (1, 3) , For The Gfrup Respiratory Study Group For The Gfrup Respiratory Study Group

1 Hôpital Arnaud de Villeneuve [CHRU Montpellier]
2 UMRESTTE UMR T9405 - Unité Mixte de Recherche Epidémiologique et de Surveillance Transport Travail Environnement
3 UM - Université de Montpellier

High-flow nasal cannula (HFNC) therapy is increasingly proposed as first-line respiratory support for infants with acute viral bronchiolitis (AVB). Most teams use 2 L/kg/min, but no study compared different flow rates in this setting. We hypothesized that 3 L/kg/min would be more efficient for the initial management of these patients.

Mots clés: BRONCHIOLITIS; HIGH-FLOW NASAL CANNULA; INFANT; NONINVASIVE VENTILATION

Domaines: Santé publique et épidémiologie

Christophe Milesi, Anne-Florence Pierre, Anna Deho, Robin Pouyau, Jean-Michel Liet, et al.. A multicenter randomized controlled trial of a 3-L/kg/min versus 2-L/kg/min high-flow nasal cannula flow rate in young infants with severe viral bronchiolitis (TRAMONTANE 2). Intensive Care Medicine, 2018, 44 (11), pp. 1870-1878. ⟨10.1007/s00134-018-5343-1⟩. ⟨hal-02050422⟩