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Absence of involvement of nitric oxide in LP-BM5-induced immunodeficiency syndrome

Abstract : To examine the role of nitric oxide (NO) in murine AIDS (MAIDS) pathogenesis, we determined NO production and inducible NOS (iNOS) mRNA expression in the macrophages of LP-BM5-infected mice, together with the in vivo effects of L-NAME, a competitive inhibitor of NO synthase. LP-BM5 infection induced neither spontaneous nitrite production nor iNOS mRNA expression. No differences in IFN gamma + LPS-induced nitrite production or iNOS mRNA expression were observed in macrophages, from non-infected or infected mice. Spleen weight, ecotropic MuLV replication, the blood lymphocyte phenotype and proliferative response of splenocytes were not modified by L-NAME. LP-BM5 infection did not increase macrophage NO production and NO production did not appear to protect against LP-BM5-induced immunodeficiency.
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Contributor : Benoît Chénais Connect in order to contact the contributor
Submitted on : Wednesday, February 27, 2019 - 10:38:31 AM
Last modification on : Monday, September 16, 2019 - 3:00:03 PM


  • HAL Id : hal-02050420, version 1



K. Akarid, B. Chénais, F. Chau, M. Sinet, B. Desforges, et al.. Absence of involvement of nitric oxide in LP-BM5-induced immunodeficiency syndrome. FEMS Immunology & Medical Microbiology, 1996, 15 (2-3), pp.169-176. ⟨hal-02050420⟩



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