Evaluation of polyol-made Gd3+ -substituted Co0.6Zn0.4Fe2O4 nanoparticles as high magnetization MRI negative contrast agents

Abstract : The structural, microstructural, and magnetic properties of ~5‐nm‐sized Co0.6Zn0.4Fe2−xGdxO4 nanoparticles were investigated in order to evaluate their capability to enhance the magnetic resonance imaging contrast as high magnetization agents. A focus was made on the solubility of Gd3+ cations within the spinel lattice. By coupling X‐ray diffraction to X‐ray fluorescence spectroscopy, we demonstrated that only a limited fraction of Gd3+ can substitute Fe3+ ions into the whole crystal structure and does not exceed 6 at.‐%. At this concentration, the room temperature (27°C) saturation magnetizations of the prepared superparamagnetic nanocrystals were found to be close to 80 emu g−1. Coating these nanoparticles with hydrophilic dopamine ligands leads to the formation of ~50‐nm‐sized clusters in water. As a consequence, relatively high r2/r1 ratios of transverse to longitudinal proton relaxivities and high r2 values were measured in the resulting colloids at physiological temperature (37°C) for an applied magnetic field of 1.41 T: 33 and 188 mM−1 sec−1, respectively, for the richest system in gadolinium. Moreover, after incubation with healthy human model cells (fibroblasts) at doses as high as 10 μg mL−1, they induce neither cellular death nor acute cellular damage making the engineered probes particularly valuable for negative magnetic resonance imaging contrasting.
Document type :
Journal articles
Complete list of metadatas

Cited literature [30 references]  Display  Hide  Download

Contributor : Olivier Sandre <>
Submitted on : Thursday, April 25, 2019 - 5:21:11 PM
Last modification on : Monday, July 1, 2019 - 11:00:03 AM


Publisher files allowed on an open archive


Distributed under a Creative Commons Attribution - NonCommercial - NoDerivatives 4.0 International License




Walid Mnasri, Lotfi Bentahar, Sophie Nowak, Olivier Sandre, Michel Boissière, et al.. Evaluation of polyol-made Gd3+ -substituted Co0.6Zn0.4Fe2O4 nanoparticles as high magnetization MRI negative contrast agents. Journal of Interdisciplinary Nanomedicine, 2019, 4 (1), pp.4-23. ⟨https://onlinelibrary.wiley.com/doi/full/10.1002/jin2.53⟩. ⟨10.1002/jin2.53⟩. ⟨hal-02023187v2⟩



Record views


Files downloads