Evaluation of polyol-made Gd3+ -substituted Co0.6Zn0.4Fe2O4 nanoparticles as high magnetization MRI negative contrast agents

Abstract : The structural, microstructural, and magnetic properties of ~5‐nm‐sized Co0.6Zn0.4Fe2−xGdxO4 nanoparticles were investigated in order to evaluate their capability to enhance the magnetic resonance imaging contrast as high magnetization agents. A focus was made on the solubility of Gd3+ cations within the spinel lattice. By coupling X‐ray diffraction to X‐ray fluorescence spectroscopy, we demonstrated that only a limited fraction of Gd3+ can substitute Fe3+ ions into the whole crystal structure and does not exceed 6 at.‐%. At this concentration, the room temperature (27°C) saturation magnetizations of the prepared superparamagnetic nanocrystals were found to be close to 80 emu g−1. Coating these nanoparticles with hydrophilic dopamine ligands leads to the formation of ~50‐nm‐sized clusters in water. As a consequence, relatively high r2/r1 ratios of transverse to longitudinal proton relaxivities and high r2 values were measured in the resulting colloids at physiological temperature (37°C) for an applied magnetic field of 1.41 T: 33 and 188 mM−1 sec−1, respectively, for the richest system in gadolinium. Moreover, after incubation with healthy human model cells (fibroblasts) at doses as high as 10 μg mL−1, they induce neither cellular death nor acute cellular damage making the engineered probes particularly valuable for negative magnetic resonance imaging contrasting.
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Walid Mnasri, Lotfi Bentahar, Sophie Nowak, Olivier Sandre, Michel Boissière, et al.. Evaluation of polyol-made Gd3+ -substituted Co0.6Zn0.4Fe2O4 nanoparticles as high magnetization MRI negative contrast agents. Journal of Interdisciplinary Nanomedicine, 2019, 4 (1), pp.4-23. ⟨https://onlinelibrary.wiley.com/doi/full/10.1002/jin2.53⟩. ⟨10.1002/jin2.53⟩. ⟨hal-02023187v2⟩

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