Michael addition of 1,3-dicarbonyl compounds catalyzed by iron oxide nanoparticles

Meriam Jebari (1) , Nabil Bouazizi (1) , Radhouane Bargougui (1) , Farhat Rezgui , Jacques Maddaluno (2, 1) , Franck Le Derf (1) , Julien Vieillard (1) , Julien Legros (1)

1 COBRA - Chimie Organique et Bioorganique : Réactivité et Analyse
2 INC-CNRS - Institut de Chimie - CNRS Chimie

Several iron oxides nanoparticles (Fe2O3@Fe2O3, Fe°@Fe2O3, GO@Fe2O3 and calcinated Fe2O3) have been assessed as catalysts in the 1,4-addition of a cyclic β-ketoester onto methyl vinyl ketone under neat conditions. It appeared that calcinated Fe2O3NP are efficient catalysts at 1 mol% loading for the Michael addition of 1,3-dicarbonyl compounds onto various enones.

Domaines: Chimie organique

Meriam Jebari, Nabil Bouazizi, Radhouane Bargougui, Farhat Rezgui, Jacques Maddaluno, et al.. Michael addition of 1,3-dicarbonyl compounds catalyzed by iron oxide nanoparticles. Tetrahedron Letters, 2018, 59 (45), pp.4044-4046. ⟨10.1016/j.tetlet.2018.09.069⟩. ⟨hal-02019131⟩