Structural Basis for Galectin-1-dependent Pre-B Cell Receptor (Pre-BCR) Activation

Latifa Elantak (1) , Marion Espeli (2) , Annie Boned (3) , Olivier Bornet (4) , Jeremy Bonzi , Laurent Gauthier (5) , Mikael Feracci (6) , Philippe Roche (7) , Francoise Guerlesquin (1) , Claudine Schiff (3)

1 LISM - Laboratoire d'ingénierie des systèmes macromoléculaires
2 Cytokines, chimiokines et immunopathologie
3 CIML - Centre d'Immunologie de Marseille - Luminy
4 IMR - Interactions et Modulateurs de Réponses
5 Agroscope
6 Univ Leicester, Dept Mol & Cell Biol, Henry Wellcome Bldg,Lancaster Rd, Leicester LE1 7RH, Leics, England
7 STMicroelectronics

Background: Galectin-1 (GAL1) is a ligand for the pre-BCR which is involved in the proliferation and differentiation of normal pre-BII cells. Results: GAL1-dependent pre-BCR clustering is driven mainly by hydrophobic contacts. Conclusion: Constitutive and ligand-induced pre-BCR activation can occur in a complementary manner. Significance: This is the first molecular snapshot of a pre-BCR/ligand interaction that helps pre-BCR clustering and activation.

Domaines: Sciences du Vivant [q-bio]; Biochimie, Biologie Moléculaire; Biologie structurale [q-bio.BM]

Latifa Elantak, Marion Espeli, Annie Boned, Olivier Bornet, Jeremy Bonzi, et al.. Structural Basis for Galectin-1-dependent Pre-B Cell Receptor (Pre-BCR) Activation. Journal of Biological Chemistry, 2012, 287 (53), pp.44703-44713. ⟨10.1074/jbc.m112.395152⟩. ⟨hal-02018151⟩