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Structural Basis for Galectin-1-dependent Pre-B Cell Receptor (Pre-BCR) Activation

Abstract : Background: Galectin-1 (GAL1) is a ligand for the pre-BCR which is involved in the proliferation and differentiation of normal pre-BII cells. Results: GAL1-dependent pre-BCR clustering is driven mainly by hydrophobic contacts. Conclusion: Constitutive and ligand-induced pre-BCR activation can occur in a complementary manner. Significance: This is the first molecular snapshot of a pre-BCR/ligand interaction that helps pre-BCR clustering and activation.
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https://hal.archives-ouvertes.fr/hal-02018151
Contributor : Latifa Elantak Connect in order to contact the contributor
Submitted on : Wednesday, February 13, 2019 - 4:13:19 PM
Last modification on : Tuesday, October 19, 2021 - 10:59:26 PM
Long-term archiving on: : Tuesday, May 14, 2019 - 4:35:39 PM

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Latifa Elantak, Marion Espeli, Annie Boned, Olivier Bornet, Jeremy Bonzi, et al.. Structural Basis for Galectin-1-dependent Pre-B Cell Receptor (Pre-BCR) Activation. Journal of Biological Chemistry, American Society for Biochemistry and Molecular Biology, 2012, 287 (53), pp.44703-44713. ⟨10.1074/jbc.m112.395152⟩. ⟨hal-02018151⟩

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