Phylogenetic and functional analysis of the Cation Diffusion Facilitator (CDF) family: improved signature and prediction of substrate specificity

Barbara Montanini (1, 2) , Damien Blaudez (2) , Sylvain Jeandroz (2) , Dale Sanders (3) , Michel Chalot (2)

1 UNIPR - Università degli studi di Parma = University of Parma
2 IAM - Interactions Arbres-Microorganismes
3 Structural Biology Laboratory, Department of Chemistry, University of York

The Cation Diffusion Facilitator (CDF) family is a ubiquitous family of heavy metal transporters. Much interest in this family has focused on implications for human health and bioremediation. In this work a broad phylogenetic study has been undertaken which, considered in the context of the functional characteristics of some fully characterised CDF transporters, has aimed at identifying molecular determinants of substrate selectivity and at suggesting metal specificity for newly identified CDF transporters.

Mots clés: Synthetic Define; Cation Diffusion Facilitator; Metal Specificity; Conserve Glycine Residue

Domaines: Systématique, phylogénie et taxonomie

Barbara Montanini, Damien Blaudez, Sylvain Jeandroz, Dale Sanders, Michel Chalot. Phylogenetic and functional analysis of the Cation Diffusion Facilitator (CDF) family: improved signature and prediction of substrate specificity. BMC Genomics, 2007, 8 (1), pp.107. ⟨10.1186/1471-2164-8-107⟩. ⟨hal-02017595⟩