pH-Sensitive Micelles for Targeted Drug Delivery Prepared Using a Novel Membrane Contactor Method - Archive ouverte HAL Accéder directement au contenu
Article Dans Une Revue ACS Applied Materials & Interfaces Année : 2013

pH-Sensitive Micelles for Targeted Drug Delivery Prepared Using a Novel Membrane Contactor Method

Résumé

A novel membrane contactor method was used to produce size-controlled poly(ethylene glycol)-beta-polycaprolactone (PEG-PCL) copolymer micelles composed of diblock copolymers with different average molecular weights, M-n (9200 or 10 400 Da) and hydrophilic fractions, f (0.67 or 0.59). By injecting 570 L m(-2) h(-1) of the organic phase (a 1 mg mL(-1) solution of PEG-PCL in tetrahydrofuran) through a microengineered nickel membrane with a hexagonal pore array and 200 mu m pore spacing into deionized water agitated at 700 rpm, the micelle size linearly increased from 92 nm for a 5-mu m pore size to 165 nm for a 40-mu m pore size. The micelle size was finely tuned by the agitation rate, transmembrane flux and aqueous to organic phase ratio. An encapsulation efficiency of 89% and a drug loading of similar to 75% (w/w) were achieved when a hydrophobic drug (vitamin E) was entrapped within the micelles, as determined by ultracentrifugation method. The drug-loaded micelles had a mean size of 146 +/- 7 nm, a polydispersity index of 0.09 +/- 0.01, and zeta potential of -19.5 +/- 0.2 mV. When drug-loaded micelles where stored for 50 h, a pH sensitive drug release was achieved and a maximum amount of vitamin E (23%) was released at the pH of 1.9. When a pH-sensitive hydrazone bond was incorporated between PEG and PCL blocks, no significant change in micelle size was observed at the same micellization conditions.

Mots clés

ACL

Dates et versions

hal-02014138 , version 1 (11-02-2019)

Identifiants

Citer

Abdallah Laouini, Konstantinos P. Koutroumanis, Catherine Charcosset, Stella Georgiadou, Hatem Fessi, et al.. pH-Sensitive Micelles for Targeted Drug Delivery Prepared Using a Novel Membrane Contactor Method. ACS Applied Materials & Interfaces, 2013, 5 (18), pp.8939-8947. ⟨10.1021/am4018237⟩. ⟨hal-02014138⟩
3 Consultations
0 Téléchargements

Altmetric

Partager

Gmail Facebook X LinkedIn More