Unexpected Interactions of an Alternating Poly(ether-ester) with Artificial and Biological Bilipidic Membranes

Nicolas Illy (1) , Laurent Bacri (2, 1) , Justyna Wojno (1) , Damien Destouches (3) , Blandine Brissault (1) , José Courty (3) , Loïc Auvray (1) , Jacques Penelle (1) , Valessa Barbier (1)

1 ICMPE - Institut de Chimie et des Matériaux Paris-Est
2 LAMBE - Laboratoire Analyse et Modélisation pour la Biologie et l'Environnement
3 CRRET - Croissance cellulaire, réparation et régénération tissulaires

The anionic polymerization of a spiro monomer containing both an ester‐activated cyclopropane moiety and a 1,4,7,10,13‐pentaoxacyclohexadecane‐14,16‐dione crown ether bislactone unexpectedly yielded a linear alternating poly(ether‐ester) via the ring‐opening polymerization of the crown ether cycle. Ion conductivity measurements using black lipid membranes as model systems showed that oligomers of this structure are able to permeabilize bilipidic membranes, with single‐ion channel behaviors being observed. Biological assays on fibroblast cells indicated a significant cytotoxicity, probably related to the above permeabilization mechanism.

Mots clés: ion transport; poly(ether‐ester); pore; cytotoxicity; bilipidic membrane

Domaines: Polymères; Matière Molle [cond-mat.soft]

Nicolas Illy, Laurent Bacri, Justyna Wojno, Damien Destouches, Blandine Brissault, et al.. Unexpected Interactions of an Alternating Poly(ether-ester) with Artificial and Biological Bilipidic Membranes. Macromolecular Symposia, 2010, 287 (1), pp.60-68. ⟨10.1002/masy.201050109⟩. ⟨hal-02006536⟩