2-Aminothiazole derivatives as selective allosteric modulators of the protein kinase CK2. Part 2: Structure–based optimization and investigation of effects specific to the allosteric mode of action

Benoît Bestgen (1) , Irina Kufareva (2) , Weiguang Seetoh , Chris Abell (3) , Rolf W Hartmann (4) , Ruben Abagyan (2) , Marc Le Borgne (1) , Odile Filhol (5) , Claude Cochet (6) , Thierry Lomberget (1) , Matthias Engel (4)

1 B2MC - Molécules bioactives et chimie médicinale
2 Skaggs School of Pharmacy and Pharmaceutical Sciences [San Diego]
3 Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
4 Saarland University [Saarbrücken]
5 U873
6 Transduction du signal : signalisation calcium, phosphorylation et inflammation

Domaines: Pharmacologie; Médicaments; Chimie thérapeutique; Chemo-informatique

Benoît Bestgen, Irina Kufareva, Weiguang Seetoh, Chris Abell, Rolf W Hartmann, et al.. 2-Aminothiazole derivatives as selective allosteric modulators of the protein kinase CK2. Part 2: Structure–based optimization and investigation of effects specific to the allosteric mode of action. Journal of Medicinal Chemistry, 2019, 62 (4), pp.1817-1836. ⟨10.1021/acs.jmedchem.8b01765⟩. ⟨hal-02004987⟩