2-Aminothiazole derivatives as selective allosteric modulators of the protein kinase CK2. Part 1: Identification of an allosteric binding site

Benoît Bestgen (1) , Isabelle Krimm (2) , Irina Kufareva (3) , Ahmed Kamal , Wei Guang Seetoh , Chris Abell (4) , Rolf W Hartmann (5) , Ruben Abagyan (3) , Claude Cochet (6) , Marc Le Borgne (1) , Matthias Engel (5) , Thierry Lomberget (1)

1 B2MC - Molécules bioactives et chimie médicinale
2 CRMN - Centre de RMN à très hauts champs de Lyon
3 Skaggs School of Pharmacy and Pharmaceutical Sciences [San Diego]
4 Univ Cambridge, Dept Chem, Cambridge CB2 1EW, England
5 Saarland University [Saarbrücken]
6 Transduction du signal : signalisation calcium, phosphorylation et inflammation

Domaines: Pharmacologie; Médicaments; Chimie thérapeutique; Chemo-informatique

Benoît Bestgen, Isabelle Krimm, Irina Kufareva, Ahmed Kamal, Wei Guang Seetoh, et al.. 2-Aminothiazole derivatives as selective allosteric modulators of the protein kinase CK2. Part 1: Identification of an allosteric binding site. Journal of Medicinal Chemistry, 2019, 62 (4), pp.1803-1816. ⟨10.1021/acs.jmedchem.8b01766⟩. ⟨hal-02004986⟩