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Article Dans Une Revue EXPERT REVIEW OF ANTI-INFECTIVE THERAPY Année : 2018

Zika virus, vaccines, and antiviral strategies

Sophie Masmejan
  • Fonction : Auteur
David Baud
  • Fonction : Auteur
Alice Panchaud
  • Fonction : Auteur

Résumé

Introduction: Zika virus (ZIKV) recently emerged as a global public health emergency of international concern. ZIKV is responsible for severe neurological complications in adults and infection during pregnancy and can lead to congenital Zika syndrome. There is no licensed vaccine or drug to prevent or treat ZIKV infection.Areas covered: The aim of this article is to provide an overview and update of the progress of research on anti-ZIKV vaccine and medications until the end of 2017, with a special emphasis on drugs that can be used during pregnancy.Expert commentary: Development of new vaccines and drugs is challenging and several points particular to ZIKV infections augment this difficulty: (1) Cross-reactions between ZIKV and other flaviviruses, the impact of ZIKV vaccination on subsequent flavivirus infections, and vice-versa, is unknown, (2) Drugs against ZIKV should be safe in pregnant women, and (3) Evaluation of the efficacy of vaccine and drugs against ZIKV in clinical trials phase II-IV will be complicated due to the decline of ZIKV circulation.
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Dates et versions

hal-02004359 , version 1 (01-02-2019)

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Citer

Sophie Masmejan, David Baud, Didier Musso, Alice Panchaud. Zika virus, vaccines, and antiviral strategies. EXPERT REVIEW OF ANTI-INFECTIVE THERAPY, 2018, 16 (6), pp.471-483. ⟨10.1080/14787210.2018.1483239⟩. ⟨hal-02004359⟩

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