Preliminary phytochemical screening and protective effect of Erythrina Senegalensis in an in vivo mouse model of Alzheimer's disease
Résumé
Erythrina senegalensis is a therapeutic plant selective extracts from bark of of the African Pharmacopoeia, widely used E. senegalensis by identification tests, and by populations in the treatment many evaluated its anti-radical activity (DPPH pathologies, including mental disorders and test) and compared to vitamin C. Finally, we cognitive impairments. We qualitatively examined its neuroprotective potential in analyzed crude methanol, acidic extracts and vivo in a pharmacological mouse model of Alzheimer's disease at the behavioral and biochemical level. The neuroprotective activity was evaluated in vivo in mice intracerebroventricularly injected with oligomeric amyloid-β25-35 peptide. The different tests were analyzed and compared to donepezil, anacetylcholinesteraseinhibitor. Sterols, terpenes, coumarins, alkaloids, flavonoids, polyphenolstannins were identified in the plant. The best inhibitory profile of DPPH radical was observed for the chloroform extract. The crude methanol extract had high neuroprotective activities in vivo.