Efficacy of acetylleucine in vertigo and dizziness: a systematic review of randomised controlled trials

Abstract : Purpose: To assess the efficacy of acetylleucine to improve or stop an attack of vertigo and dizziness (vertigo/dizziness). Methods: Systematic review by 2 independent reviewers. Consultation of the Medline, Cochrane and ClinicalTrials.gov databases until September 2018. Keywords used: Acetylleucine, Tanganil®, Acetyl-DL-leucine, Acetyl-leucine. Trial selection: randomised controlled trials (RCTs) comparing acetylleucine against placebo. Results: Up until 2018, no RCTs have been published on the efficacy of acetylleucine in vertigo/dizziness. Conclusion: There is no solid evidence of the efficacy of acetylleucine in vertigo/dizziness. Given its frequent prescription and the cost generated for the French social security system, high-quality randomised trials should be carried out to assess its efficacy.
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Submitted on : Saturday, January 19, 2019 - 10:29:01 AM
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Paul Vanderkam, Clara Blanchard, Florian Naudet, Denis Pouchain, Hélène Vaillant Roussel, et al.. Efficacy of acetylleucine in vertigo and dizziness: a systematic review of randomised controlled trials. European Journal of Clinical Pharmacology, Springer Verlag, In press, 75 (5), pp.603-607. ⟨10.1007/s00228-018-02617-6⟩. ⟨hal-01986731⟩

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