Adherence to medication is associated with non-planning impulsivity in euthymic bipolar disorder patients

Raoul Belzeaux (1, 2) , Laurent Boyer (3) , Pascale Mazzola-Pomietto (4) , Pierre Michel (3) , Nadia Correard (5, 1) , Valerie Aubin (1) , Frank Bellivier (1, 6) , Thierry Bougerol (1) , Emilie Olie (7, 8, 1) , Philippe Courtet (7, 8, 1) , Bruno Etain (9, 1) , Sébastien Gard (10, 1) , Jean-Pierre Kahn (1, 11) , Christine Passerieux (1) , Marion Leboyer (1, 12) , Chantal Henry (1, 12) , Jean-Michel Azorin (1, 13, 3)

1 Fondation FondaMental [Créteil]
2 CRN2M - Centre de recherche en neurobiologie - neurophysiologie de Marseille
3 CEReSS - Centre d'études et de recherche sur les services de santé et la qualité de vie
4 INT - Institut de Neurosciences de la Timone
5 CHU Marseille
6 Hôpitaux Universitaires Saint-Louis, Lariboisière, Fernand-Widal
7 PSNREC - Neuropsychiatrie : recherche épidémiologique et clinique
8 CHRU Montpellier - Centre Hospitalier Régional Universitaire [Montpellier]
9 IMRB - Institut Mondor de Recherche Biomédicale
10 Centre hospitalier Charles Perrens [Bordeaux]
11 UL - Université de Lorraine
12 Pôle de Psychiatrie [Hôpital Henri Mondor]
13 Hôpitaux Sud - Département Universitaire de Psychiatrie - [Hôpital Sainte Marguerite - APHM]

Background: Adherence to medication is a major issue in bipolar disorder. defined as a lack of future orientation, has been demonstrated to be the main impulsivity domain altered during euthymia in bipolar disorder patients. It was associated with comorbidities. Methods: To investigate relationship between adherence to medication and non-planning impulsivity, we included 260 euthymic bipolar patients. Adherence to medication was evaluated by Medication Adherence Rating Scale and non-planning impulsivity by Barrat Impulsiveness Scale. Univariate analyses and linear regression were used. We conducted also a path analysis to examine whether non-planning impulsivity had direct or indirect effect on adherence, mediated by comorbidities. Results: Adherence to medication was correlated with non-planning impulsivity, even after controlling for potential confounding factors in linear regression analysis (Beta standardized coefficient¼ 0.156; p¼ 0.015). Path analysis demonstrated only a direct effect of non-planning impulsivity on adherence to medication, and none indirect effect via substance use disorders and anxiety disorders. Limitations: Our study is limited by its cross-sectional design and adherence to medication was assessed only by self-questionnaire.

Domaines: Sciences du Vivant [q-bio]

Raoul Belzeaux, Laurent Boyer, Pascale Mazzola-Pomietto, Pierre Michel, Nadia Correard, et al.. Adherence to medication is associated with non-planning impulsivity in euthymic bipolar disorder patients. Journal of Affective Disorders, 2015, 184, pp.60--66. ⟨10.1016/j.jad.2015.05.041⟩. ⟨hal-01985796⟩