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Defective planar cell polarity in polycystic kidney disease

Abstract : Morphogenesis involves coordinated proliferation, differentiation and spatial distribution of cells. We show that lengthening of renal tubules is associated with mitotic orientation of cells along the tubule axis, demonstrating intrinsic planar cell polarization, and we demonstrate that mitotic orientations are significantly distorted in rodent polycystic kidney models. These results suggest that oriented cell division dictates the maintenance of constant tubule diameter during tubular lengthening and that defects in this process trigger renal tubular enlargement and cyst formation.
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Contributor : Jean Francois Daniel Nicolas <>
Submitted on : Tuesday, January 8, 2019 - 2:46:12 PM
Last modification on : Monday, January 13, 2020 - 5:08:07 PM




Evelyne Fischer, Emilie Legue, Antonia Doyen, Faridabano Nato, Jean-François Nicolas, et al.. Defective planar cell polarity in polycystic kidney disease. Nature Genetics, Nature Publishing Group, 2006, 38 (1), pp.21-23. ⟨10.1038/ng1701⟩. ⟨hal-01973787⟩



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