The Division of Amyloid Fibrils

Abstract : The division of amyloid protein fibrils is required for the propagation of the amyloid state, and is an important contributor to their stability, pathogenicity and normal function. Here, we combine kinetic nano-scale imaging experiments with analysis of a mathematical model to resolve and compare the division of amyloid fibrils. Our theoretical results show that the division of any type of filament is uniquely described by a set of three characteristic properties, resulting in self-similar length distributions distinct to each fibril type and conditions applied. By applying these results to profile the dynamical stability towards breakage for four different amyloid types, we reveal particular differences in the division properties of disease-and non-disease related amyloid, the former showing lowered intrinsic stability towards breakage and increased likelihood of shedding smaller particles. Our results enable the comparison of protein filaments’ intrinsic dynamic stabilities, which are key to unravelling their toxic and infectious potentials.
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Submitted on : Thursday, December 27, 2018 - 8:03:31 PM
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David Béal, Magali Tournus, Ricardo Marchante, Tracey Purton, David Smith, et al.. The Division of Amyloid Fibrils. 2018. ⟨hal-01966243⟩



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