Re-thinking our understanding of immunity: Robustness in the tissue reconstruction system

Marie-Elise Truchetet (1) , Thomas Pradeu (1)

1 ImmunoConcept - Immunology from Concept and Experiments to Translation

Robustness, understood as the maintenance of specific functionalities of a given system against internal and external perturbations, is pervasive in today's biology. Yet precise applications of this notion to the immune system have been scarce. Here we show that the concept of robustness sheds light on tissue repair, and particularly on the crucial role the immune system plays in this process. We describe the specific mechanisms, including plasticity and redundancy, by which robustness is achieved in the tissue reconstruction

Domaines: Sciences du Vivant [q-bio]; Immunologie; Biologie du développement; Médecine humaine et pathologie; Physiologie [q-bio.TO]; Dermatologie; Rhumatologie et système ostéo-articulaire; Sciences de l'Homme et Société

Marie-Elise Truchetet, Thomas Pradeu. Re-thinking our understanding of immunity: Robustness in the tissue reconstruction system. Seminars in Immunology, 2018, 36, pp.45-55. ⟨hal-01964548⟩